| S-KLASSE (W222, V222, X222) S 63 AMG (222.077, 222.177) | Benzin | 430kW / 585PS | Heckantrieb | 5461ccm | Suchen |
| S-KLASSE (W222, V222, X222) S 63 AMG 4-matic (222.178) | Benzin | 430kW / 585PS | Allrad | 5461ccm | Suchen |
| S-KLASSE (W222, V222, X222) S 500 4-matic (222.085, 222.185) | Benzin | 335kW / 455PS | Allrad | 4663ccm | Suchen |
| S-KLASSE (W222, V222, X222) S 350 BlueTEC / d (222.132, 222.032, 222.123) | Diesel | 190kW / 258PS | Heckantrieb | 2987ccm | Suchen |
| S-KLASSE (W222, V222, X222) S 400 Hybrid / h (222.057, 222.157) | Benzin/Elektro | 225kW / 306PS | Heckantrieb | 3498ccm | Suchen |
| S-KLASSE (W222, V222, X222) S 500 (222.082, 222.182) | Benzin | 335kW / 455PS | Heckantrieb | 4663ccm | Suchen |
| S-KLASSE (W222, V222, X222) S 500 (222.082, 222.182) | Benzin | 320kW / 435PS | Heckantrieb | 4663ccm | Suchen |
| S-KLASSE (W222, V222, X222) S 300 BlueTEC Hybrid / h (222.104, 222.004) | Diesel/Elektro | 170kW / 231PS | Heckantrieb | 2143ccm | Suchen |
| S-KLASSE (W222, V222, X222) S 350 BlueTEC / d 4-matic (222.033, 222.133) | Diesel | 190kW / 258PS | Allrad | 2987ccm | Suchen |
| S-KLASSE (W222, V222, X222) S 600 (222.176) | Benzin | 390kW / 530PS | Heckantrieb | 5980ccm | Suchen |
| S-KLASSE (W222, V222, X222) S 65 AMG (222.179) | Benzin | 463kW / 630PS | Heckantrieb | 5980ccm | Suchen |
| S-KLASSE (W222, V222, X222) S 350 BlueTEC 4-matic (222.133) | Diesel | 185kW / 252PS | Allrad | 2987ccm | Suchen |
| S-KLASSE (W222, V222, X222) S 320 (222.162) | Benzin | 200kW / 272PS | Heckantrieb | 2996ccm | Suchen |
| S-KLASSE (W222, V222, X222) S 500 Hybrid / e (222.163) | Benzin/Elektro | 325kW / 442PS | Heckantrieb | 2996ccm | Suchen |
| S-KLASSE (W222, V222, X222) S 400 4-matic (222.067, 222.167) | Benzin | 245kW / 333PS | Allrad | 2996ccm | Suchen |
| S-KLASSE (W222, V222, X222) S 500 Maybach (222.982) | Benzin | 335kW / 455PS | Heckantrieb | 4663ccm | Suchen |
| S-KLASSE (W222, V222, X222) S 600 Maybach (222.976) | Benzin | 390kW / 530PS | Heckantrieb | 5980ccm | Suchen |
| S-KLASSE (W222, V222, X222) S 400 Maybach 4-matic (222.967) | Benzin | 245kW / 333PS | Allrad | 2996ccm | Suchen |
| S-KLASSE (W222, V222, X222) S 500 Maybach 4-matic (222.985) | Benzin | 335kW / 455PS | Allrad | 4663ccm | Suchen |
| S-KLASSE (W222, V222, X222) S 400 (222.165) | Benzin | 245kW / 333PS | Heckantrieb | 2996ccm | Suchen |
| S-KLASSE (W222, V222, X222) S 350 d 4-matic (222.021, 222.121) | Diesel | 210kW / 286PS | Allrad | 2925ccm | Suchen |
| S-KLASSE (W222, V222, X222) S 400 d 4-matic (222.035, 222.135) | Diesel | 250kW / 340PS | Allrad | 2925ccm | Suchen |
| S-KLASSE (W222, V222, X222) S 560 4-matic (222.086, 222.186) | Benzin | 345kW / 469PS | Allrad | 3982ccm | Suchen |
| S-KLASSE (W222, V222, X222) AMG S 63 4-matic+ (222.188) | Benzin | 450kW / 612PS | Allrad | 3982ccm | Suchen |
| S-KLASSE (W222, V222, X222) S 560 Maybach 4-matic (222.986) | Benzin | 345kW / 469PS | Allrad | 3982ccm | Suchen |
| S-KLASSE (W222, V222, X222) S 450 4-matic (222.064, 222.164, 222.964) | Benzin | 270kW / 367PS | Allrad | 2996ccm | Suchen |
| S-KLASSE (W222, V222, X222) S 450 (222.066, 222.166) | Benzin | 270kW / 367PS | Heckantrieb | 2996ccm | Suchen |
| S-KLASSE (W222, V222, X222) S 650 Maybach (222.980) | Benzin | 463kW / 630PS | Heckantrieb | 5980ccm | Suchen |
| S-KLASSE (W222, V222, X222) S 560 Maybach (222.983) | Benzin | 345kW / 469PS | Heckantrieb | 3982ccm | Suchen |
| S-KLASSE (W222, V222, X222) S 400 d (222.034, 222.134) | Diesel | 250kW / 340PS | Heckantrieb | 2925ccm | Suchen |
| S-KLASSE (W222, V222, X222) S 350 d (222.020, 222.120) | Diesel | 210kW / 286PS | Heckantrieb | 2925ccm | Suchen |
| S-KLASSE (W222, V222, X222) S 560 (222.083, 222.183) | Benzin | 345kW / 469PS | Heckantrieb | 3982ccm | Suchen |
| S-KLASSE (W222, V222, X222) S 450 EQ Boost (222.158, 222.058) | Benzin/Elektro | 270kW / 367PS | Heckantrieb | 2999ccm | Suchen |
| S-KLASSE (W222, V222, X222) S 450 EQ Boost 4-matic (222.059, 222.159) | Benzin/Elektro | 270kW / 367PS | Allrad | 2999ccm | Suchen |
| S-KLASSE (W222, V222, X222) S 500 EQ Boost (222.060, 222.160) | Benzin/Elektro | 320kW / 435PS | Heckantrieb | 2999ccm | Suchen |
| S-KLASSE (W222, V222, X222) S 450 Maybach 4-matic (222.964) | Benzin | 270kW / 367PS | Allrad | 2996ccm | Suchen |
| S-KLASSE (W222, V222, X222) AMG S 63 (222.187) | Benzin | 450kW / 612PS | Heckantrieb | 3982ccm | Suchen |
| S-KLASSE (W222, V222, X222) S 350 d 4-matic (222.121) | Diesel | 183kW / 249PS | Allrad | 2925ccm | Suchen |
| S-KLASSE (W222, V222, X222) S 500 4-matic (222.185) | Benzin | 320kW / 435PS | Allrad | 4663ccm | Suchen |
| S-KLASSE (W222, V222, X222) S 560 e (222.173) | Benzin/Elektro | 350kW / 476PS | Heckantrieb | 2996ccm | Suchen |
| S-KLASSE (W222, V222, X222) S 650 Maybach (222.980) | Benzin | 390kW / 530PS | Heckantrieb | 5980ccm | Suchen |