| S-KLASSE (W221, V221) S 400 Hybrid (221.095, 221.195) | Benzin/Elektro | 205kW / 279PS | Heckantrieb | 3498ccm | Suchen |
| S-KLASSE (W221, V221) S 63 AMG (221.074, 221.174) | Benzin | 420kW / 571PS | Heckantrieb | 5461ccm | Suchen |
| S-KLASSE (W221, V221) S 250 CDI (221.003, 221.103) | Diesel | 150kW / 204PS | Heckantrieb | 2143ccm | Suchen |
| S-KLASSE (W221, V221) S 350 BlueTec (221.026, 221.126) | Diesel | 190kW / 258PS | Heckantrieb | 2987ccm | Suchen |
| S-KLASSE (W221, V221) S 350 BlueTEC 4-matic (221.083, 221.183) | Diesel | 190kW / 258PS | Allrad | 2987ccm | Suchen |
| S-KLASSE (W221, V221) S 350 CGI (221.057, 221.157) | Benzin | 225kW / 306PS | Heckantrieb | 3498ccm | Suchen |
| S-KLASSE (W221, V221) S 350 CGI 4-matic (221.082, 221.182) | Benzin | 225kW / 306PS | Allrad | 3498ccm | Suchen |
| S-KLASSE (W221, V221) S 500 CGI (221.073, 221.173) | Benzin | 320kW / 435PS | Heckantrieb | 4663ccm | Suchen |
| S-KLASSE (W221, V221) S 500 CGI 4-matic (221.094, 221.194) | Benzin | 320kW / 435PS | Allrad | 4663ccm | Suchen |
| S-KLASSE (W221, V221) S 63 AMG (221.074, 221.174) | Benzin | 400kW / 544PS | Heckantrieb | 5461ccm | Suchen |
| S-KLASSE (W221, V221) S 65 AMG (221.179) | Benzin | 463kW / 630PS | Heckantrieb | 5980ccm | Suchen |
| S-KLASSE (W221, V221) S 350 CDI (221.022, 221.122) | Diesel | 173kW / 235PS | Heckantrieb | 2987ccm | Suchen |
| S-KLASSE (W221, V221) S 350 (221.056, 221.156) | Benzin | 200kW / 272PS | Heckantrieb | 3498ccm | Suchen |
| S-KLASSE (W221, V221) S 500 (221.071, 221.171) | Benzin | 285kW / 388PS | Heckantrieb | 5461ccm | Suchen |
| S-KLASSE (W221, V221) S 320 CDI (221.022, 221.122) | Diesel | 173kW / 235PS | Heckantrieb | 2987ccm | Suchen |
| S-KLASSE (W221, V221) S 450, S 450 L (221.070, 221.170) | Benzin | 250kW / 340PS | Heckantrieb | 4663ccm | Suchen |
| S-KLASSE (W221, V221) S 450 4-matic (221.084, 221.184) | Benzin | 250kW / 340PS | Allrad | 4663ccm | Suchen |
| S-KLASSE (W221, V221) S 600 (221.176) | Benzin | 380kW / 517PS | Heckantrieb | 5513ccm | Suchen |
| S-KLASSE (W221, V221) S 65 AMG (221.179) | Benzin | 450kW / 612PS | Heckantrieb | 5980ccm | Suchen |
| S-KLASSE (W221, V221) S 320 CDI 4-matic (221.080, 221.180) | Diesel | 173kW / 235PS | Allrad | 2987ccm | Suchen |
| S-KLASSE (W221, V221) S 420 CDI (221.028, 221.128) | Diesel | 235kW / 320PS | Heckantrieb | 3996ccm | Suchen |
| S-KLASSE (W221, V221) S 500 4-matic (221.086, 221.186) | Benzin | 285kW / 388PS | Allrad | 5461ccm | Suchen |
| S-KLASSE (W221, V221) S 63 AMG (221.077, 221.177) | Benzin | 386kW / 525PS | Heckantrieb | 6208ccm | Suchen |
| S-KLASSE (W221, V221) S 350 4-matic (221.087, 221.187) | Benzin | 200kW / 272PS | Allrad | 3498ccm | Suchen |
| S-KLASSE (W221, V221) S 320 CDI | Diesel | 155kW / 211PS | Heckantrieb | 2987ccm | Suchen |
| S-KLASSE (W221, V221) S 350 CDI | Diesel | 155kW / 211PS | Heckantrieb | 2987ccm | Suchen |
| S-KLASSE (W221, V221) S 280 (221.054) | Benzin | 170kW / 231PS | Heckantrieb | 2996ccm | Suchen |
| S-KLASSE (W221, V221) S 300 (221.054, 221.154) | Benzin | 170kW / 231PS | Heckantrieb | 2996ccm | Suchen |
| S-KLASSE (W221, V221) S 320 CDI 4-matic (221.080, 221.180) | Diesel | 155kW / 211PS | Allrad | 2987ccm | Suchen |
| S-KLASSE (W221, V221) S 350 CDI 4-matic (221.080, 221.081) | Diesel | 155kW / 211PS | Allrad | 2987ccm | Suchen |
| S-KLASSE (W221, V221) S 450 CDI (221.028, 221.128) | Diesel | 235kW / 320PS | Heckantrieb | 3996ccm | Suchen |
| S-KLASSE (W221, V221) S 350 CDI 4-matic (221.080, 221.180) | Diesel | 173kW / 235PS | Allrad | 2987ccm | Suchen |
| S-KLASSE (W221, V221) S 550 (221.073, 221.173) | Benzin | 320kW / 435PS | Heckantrieb | 4663ccm | Suchen |