| CLS (C218) CLS 350 (218.359) | Benzin | 225kW / 306PS | Heckantrieb | 3498ccm | Suchen |
| CLS (C218) CLS 250 CDI / BlueTEC / d (218.303, 218.304) | Diesel | 150kW / 204PS | Heckantrieb | 2143ccm | Suchen |
| CLS (C218) CLS 350 CDI / d (218.323) | Diesel | 195kW / 265PS | Heckantrieb | 2987ccm | Suchen |
| CLS (C218) CLS 63 AMG (218.374) | Benzin | 386kW / 525PS | Heckantrieb | 5461ccm | Suchen |
| CLS (C218) CLS 500 (218.373) | Benzin | 300kW / 408PS | Heckantrieb | 4663ccm | Suchen |
| CLS (C218) CLS 500 4-matic (218.391) | Benzin | 300kW / 408PS | Allrad | 4663ccm | Suchen |
| CLS (C218) CLS 350 CDI / d 4-matic (218.393) | Diesel | 195kW / 265PS | Allrad | 2987ccm | Suchen |
| CLS (C218) CLS 63 AMG (218.374) | Benzin | 410kW / 558PS | Heckantrieb | 5461ccm | Suchen |
| CLS (C218) CLS 63 AMG 4-matic (218.392) | Benzin | 410kW / 558PS | Allrad | 5461ccm | Suchen |
| CLS (C218) CLS 63 AMG 4-matic (218.376) | Benzin | 430kW / 585PS | Allrad | 5461ccm | Suchen |
| CLS (C218) CLS 63 AMG (218.375) | Benzin | 430kW / 585PS | Heckantrieb | 5461ccm | Suchen |
| CLS (C218) CLS 350 BlueTEC / d (218.326) | Diesel | 185kW / 252PS | Heckantrieb | 2987ccm | Suchen |
| CLS (C218) CLS 350 BlueTEC / d 4-matic (218.394) | Diesel | 185kW / 252PS | Allrad | 2987ccm | Suchen |
| CLS (C218) CLS 220 BlueTEC / d (218.301) | Diesel | 120kW / 163PS | Heckantrieb | 2143ccm | Suchen |
| CLS (C218) CLS 220 BlueTEC / d (218.301) | Diesel | 125kW / 170PS | Heckantrieb | 2143ccm | Suchen |
| CLS (C218) CLS 220 BlueTEC / d (218.301) | Diesel | 130kW / 177PS | Heckantrieb | 2143ccm | Suchen |
| CLS (C218) CLS 250 BlueTEC / d 4-matic (218.397) | Diesel | 150kW / 204PS | Allrad | 2143ccm | Suchen |
| CLS (C218) CLS 350 BlueTEC / d (218.326) | Diesel | 190kW / 258PS | Heckantrieb | 2987ccm | Suchen |
| CLS (C218) CLS 400 (218.365) | Benzin | 245kW / 333PS | Heckantrieb | 2996ccm | Suchen |
| CLS (C218) CLS 400 4-matic (218.367) | Benzin | 245kW / 333PS | Allrad | 2996ccm | Suchen |
| CLS (C218) CLS 400 (218.361) | Benzin | 245kW / 333PS | Heckantrieb | 3498ccm | Suchen |
| CLS (C218) CLS 400 4-matic (218.368) | Benzin | 245kW / 333PS | Allrad | 3498ccm | Suchen |
| CLS (C218) CLS 350 d 4-matic (218.394) | Diesel | 190kW / 258PS | Allrad | 2987ccm | Suchen |